2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

Related Products

PDF 3.24 MB

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

E3 Ligase Ligand-Linker Conjugates Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W584515
    Thalidomide-NH-(CH2)3-NH-Boc 2093386-36-6
    Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)3-NH-Boc is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules targeting 11β-substituted estradiol.
    Thalidomide-NH-(CH2)3-NH-Boc
  • HY-159679
    E3 Ligase Ligand-linker Conjugate 116 2409844-90-0
    E3 Ligase Ligand-linker Conjugate 116 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 116 can be used to synthesize PROTAC SMARCA2/4-degrader-28 (HY-162835).
    E3 Ligase Ligand-linker Conjugate 116
  • HY-W1006706
    E3 Ligase Ligand-linker Conjugate 157 2502189-47-9
    E3 Ligase Ligand-linker Conjugate 157 is the conjugate composed of the E3 ligase ligand and the linker. E3 Ligase Ligand-linker Conjugate 157 can be used for synthesis of PROTAC degrader KT-253 (HY-170451).
    E3 Ligase Ligand-linker Conjugate 157
  • HY-138847
    Thalidomide-O-C3-NH2 2509360-22-7
    Thalidomide-O-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-O-C3-NH2
  • HY-159683
    E3 Ligase Ligand-linker Conjugate 117
    E3 Ligase Ligand-linker Conjugate 117 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 117 can be used to synthesize PROTAC SMARCA2/4-degrader-29 (HY-162743).
    E3 Ligase Ligand-linker Conjugate 117
  • HY-168235
    (S,R,S)-AHPC-Me-amide-C9-acid 2376139-66-9
    (S,R,S)-AHPC-Me-amide-C9-acid is a E3 ligase ligand-linker conjugate, used for the synthesis of PROTAC SMARCA2 degrader-31 (HY-168234).
    (S,R,S)-AHPC-Me-amide-C9-acid
  • HY-172185
    E3 Ligase Ligand-linker Conjugate 172
    E3 Ligase Ligand-linker Conjugate 172 is the conjugate composed of an E3 ligase ligand and a linker, and can be used for synthesis of PROTAC degrader FF2039 (HY-172159).
    E3 Ligase Ligand-linker Conjugate 172
  • HY-174220
    Boc-Dipiperidine-KLHDC2 ligand 1
    Boc-Dipiperidine-KLHDC2 ligand 1 is an E3 ligase ligand-linker conjugate that incorporates a KLHDC2 ligand (HY-174218). Boc-Dipiperidine-KLHDC2 ligand 1 can be used for synthesis of PROTAC BRD4 Degrader-31 (HY-174210).
    Boc-Dipiperidine-KLHDC2 ligand 1
  • HY-145715
    Azido-PEG2-VHL 2597167-22-9
    Azido-PEG2-VHL is a multikinase degrader which can be used in the synthesis of PROTACs. Azido-PEG2-VHL is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-VHL
  • HY-157747
    E3 Ligase Ligand-linker Conjugate 99
    E3 Ligase Ligand-linker Conjugate 99 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 99 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 Ligase Ligand-linker Conjugate 99
  • HY-157515
    Thalidomide 4'-ether-PEG2-azide 2758431-90-0
    Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs.
    Thalidomide 4'-ether-PEG2-azide
  • HY-168672
    E3 Ligase Ligand-linker Conjugate 133 3052750-99-6
    E3 Ligase Ligand-linker Conjugate 133 is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete PROTAC molecule pan-KRAS degrader 4 (HY-168669).
    E3 Ligase Ligand-linker Conjugate 133
  • HY-157511
    Thalidomide-O-C5-azide 2411098-96-7
    Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs.
    Thalidomide-O-C5-azide
  • HY-132938
    (S,R,S)-AHPC-Me-decanedioic acid 2380273-45-8
    (S,R,S)-AHPC-Me-decanedioic acid is an E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs.
    (S,R,S)-AHPC-Me-decanedioic acid
  • HY-163961A
    Thalidomide-NH-cyclohexane-NH-Ph-NH2
    Thalidomide-NH-cyclohexane-NH-Ph-NH2 is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-NH-cyclohexane-NH-Ph-NH2 can be used to synthesize PROTAC erf3a Degrader-2 (HY-163938A).
    Thalidomide-NH-cyclohexane-NH-Ph-NH2
  • HY-136272
    A 410099.1 amide-PEG3-amine-Boc 2415256-19-6
    A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand for PROTACs that incorporates an IAP ligand and an amide-PEG3 linker with terminal amine. A 410099.1 amide-PEG3-amine-Boc can conjugates with target protein ligands.
    A 410099.1 amide-PEG3-amine-Boc
  • HY-W584520
    Thalidomide-4-NH-PEG1-NH-Boc 2154342-17-1
    Thalidomide-4-NH-PEG1-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-4-NH-PEG1-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
    Thalidomide-4-NH-PEG1-NH-Boc
  • HY-163235
    Phenyl phenylcarbamate-CH-5-methoxypicolinamide-CH-CH-Ph-CF3
    Phenyl phenylcarbamate-CH-5-methoxypicolinamide-CH-CH-Ph-CF3 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.
    Phenyl phenylcarbamate-CH-5-methoxypicolinamide-CH-CH-Ph-CF3
  • HY-157748
    E3 Ligase Ligand-linker Conjugate 100
    E3 Ligase Ligand-linker Conjugate 100 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 100 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 Ligase Ligand-linker Conjugate 100
  • HY-170980
    E3 Ligase Ligand-linker Conjugate 166 2930001-60-6
    E3 Ligase Ligand-linker Conjugate 166 is the conjugate composed of a E3 ligase ligand and a linker. E3 Ligase Ligand-linker Conjugate 166 can be used for synthesis of PROTAC CDK9 degrader-11 (HY-170978).
    E3 Ligase Ligand-linker Conjugate 166
Cat. No. Product Name / Synonyms Application Reactivity
E3 Ligase Ligand-Linker Conjugates Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.